Crohn’s, UC, PsO & PsA Treatment Medication

YES to proven safety and effectiveness

YESINTEK is an FDA-approved treatment that works as well and is as safe as Stelara to provide you with symptom relief.^1–3

WHAT IS A BIOSIMILAR?

A biosimilar is a biologic drug that’s highly similar to the original approved medicine. This means there are no clinically meaningful differences in safety or effectiveness between the two drugs.³

29G NEEDLE¹ Thinner needle size than Stelara

NEEDLE COVER¹
Covers the needle for your safety

NEEDLE SAFETY GUARD¹  Prevents needlestick injuries

MADE WITHOUT DRY RUBBER LATEX⁴ Reduces allergic reactions

CITRATE FREE¹  Minimizes injection site pain

YESINTEK IS INDICATED FOR THE INFLAMMATORY DISEASES BELOW¹

Select a condition below to view dosing

For adults

TO GET STARTED*
One-time intravenous (IV) infusion
TO KEEP GOING^†
Subcutaneous injection (under the skin) every 8 weeks

^*Given by your doctor in a comfortable setting. It takes at least 1 hour to receive the full dose of medicine.

^†After the one-time IV infusion, you will take YESINTEK as an injection under the skin every 8 weeks.

YESINTEK has the same dosing as Stelara. If you are switching from Stelara to YESINTEK, you do not need to repeat the one-time IV infusion and should transition at your next scheduled dose. Always check with your doctor to confirm your dose.^1,2

For adults

TO GET STARTED*
One-time intravenous (IV) infusion
TO KEEP GOING^†
Subcutaneous injection (under the skin) every 8 weeks

^*Given by your doctor in a comfortable setting. It takes at least 1 hour to receive the full dose of medicine.

^†After the one-time IV infusion, you will take YESINTEK as an injection under the skin every 8 weeks.

YESINTEK has the same dosing as Stelara. If you are switching from Stelara to YESINTEK, you do not need to repeat the one-time IV infusion and should transition at your next scheduled dose. Always check with your doctor to confirm your dose.^1,2

For adults & children 6 years and older

TO KEEP GOING*
Once every 12 weeks

^*YESINTEK should be taken as an injection under the skin at Weeks 0 and 4, then every 12 weeks after.

For adults & children 6 years and older

TO KEEP GOING*
Once every 12 weeks

^*YESINTEK should be taken as an injection under the skin at Weeks 0 and 4, then every 12 weeks after.

YES to online injection training

You’re not alone in this. We’re here to guide you through the injection process with this easy-to-follow video tutorial—so you can feel confident using YESINTEK.

You can also download the full Instructions for Use for detailed illustrations on how to use the prefilled syringe.

YES to
solid savings
and support

We’ve got your back. Through My Biocon Biologics™, you’ll gain access to helpful resources for YESINTEK and may receive assistance in out-of-pocket costs.*

*Eligibility restrictions apply. Not valid for uninsured patients or patients who are covered by a state- or federally funded healthcare program. For full terms and conditions, click here.

The answer is

Yes

Biosimilars aren’t just what we do—
they’re all we do.

Biocon Biologics is fully committed to making a meaningful difference by delivering affordable global access to high-quality biosimilars such as YESINTEK.

Learn more about us at

REFERENCES

1. YESINTEK. Prescribing information. Biocon Biologics Inc; 2024. 2. STELARA. Prescribing information. Janssen Pharmaceutical Companies; 2024. 3. US Food and Drug Administration. Biosimilars: review and approval. Last updated December 13, 2022. Accessed March 11, 2024. https://www.fda.gov/drugs/biosimilars/review-and-approval 4. Data on file. Biocon Biologics; 2024.

WHAT IS YESINTEK (ustekinumab-kfce)?

YESINTEK is a prescription medicine used to treat: adults and children 6 years and older with moderate to severe psoriasis who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills); adults and children 6 years and older with active psoriatic arthritis; adults 18 years and older with moderately to severely active Crohn’s disease; adults 18 years and older with moderately to severely active ulcerative colitis.
It is not known if YESINTEK is safe and effective in children less than 6 years of age.

IMPORTANT SAFETY INFORMATION

YESINTEK is a prescription medicine that affects your immune system. YESINTEK can increase your chance of having serious side effects including:

Serious Infections
YESINTEK may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have serious infections, which may require hospitalization, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses. Some people have to be hospitalized for treatment of their infection.

Your doctor should check you for TB before starting YESINTEK.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with YESINTEK and during treatment with YESINTEK.
Your doctor should watch you closely for signs and symptoms of TB while you are being treated with YESINTEK.
You should not start taking YESINTEK if you have any kind of infection unless your doctor says it is okay.

Before starting YESINTEK, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

are being treated for an infection or have any open cuts.
get a lot of infections or have infections that keep coming back.
have TB or have been in close contact with someone with TB.

After starting YESINTEK, call your doctor right away
if you have any symptoms of an infection (see above). These may be signs of infections such as chest infections, or skin infections or shingles that could have serious complications. YESINTEK can make you more likely to get infections or make an infection that you have worse.
People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections. These infections can spread throughout the body and cause death. People who take YESINTEK may also be more likely to get these infections.

Cancers:YESINTEK may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who are receiving ustekinumab products and have risk factors for skin cancer developed certain types of skin cancers. During your treatment with YESINTEK, tell your doctor if you have any new skin growths.

Posterior Reversible Encephalopathy Syndrome (PRES):PRES is a rare condition that affects the brain and can cause death. The cause of PRES is not known. If PRES is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including headache, seizures, confusion, and vision problems.

Serious Allergic Reactions:Serious allergic reactions can occur with YESINTEK. Stop using YESINTEK and get medical help right away if you have any symptoms of a serious allergic reaction such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Lung Inflammation: Cases of lung inflammation have happened in some people who receive ustekinumab and may be serious. These lung problems may need to be treated in a hospital. Tell your doctor right away if you develop shortness of breath or a cough that doesn’t go away during treatment with YESINTEK.

Common side effects of YESINTEK include:nasal congestion, sore throat, and runny nose, redness at the injection site, upper respiratory infections, vaginal, yeast infections, fever, urinary tract infections, headache, sinus infection, tiredness, bronchitis, itching, diarrhea, nausea and vomiting, stomach pain. These are not all of the possible side effects with YESINTEK. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Before you receive YESINTEK, tell your doctor about all of your medical conditions, including if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or PRES.
ever had an allergic reaction to ustekinumab or any of its ingredients. Ask your doctor if you are not sure.
have recently received or are scheduled to receive an immunization (vaccine). People who take YESINTEK should not receive live vaccines. Tell your doctor if anyone in your house needs a live vaccine. The viruses used in some types of live vaccines can spread to people with a weakened immune system and can cause serious problems. You should not receive the BCG vaccine during the one year before receiving YESINTEK or one year after you stop receiving YESINTEK.
have any new or changing lesions within psoriasis areas or on normal skin.
are receiving or have received allergy shots, especially for serious allergic reactions. Allergy shots may not work as well for you during treatment with YESINTEK. YESINTEK may also increase your risk of having an allergic reaction to an allergy shot.
receive or have received phototherapy for your psoriasis.
are pregnant or plan to become pregnant. It is not known if YESINTEK can harm your unborn baby. You and your doctor should decide if you will receive YESINTEK.
received YESINTEK while you were pregnant. It is important that you tell your baby’s healthcare provider before any vaccinations are given to your baby.
are breastfeeding or plan to breastfeed. YESINTEK can pass into your breast milk.
talk to your doctor about the best way to feed your baby if you receive YESINTEK.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When prescribed YESINTEK:

Use YESINTEK exactly as your doctor tells you to.
Adults with Crohn’s disease and ulcerative colitis will receive the first dose of YESINTEK through a vein in the arm (intravenous infusion) in a healthcare facility by a healthcare provider. It takes at least 1 hour to receive the full dose of medicine. You will then receive YESINTEK as an injection under the skin (subcutaneous injection)  8 weeks after the first dose of YESINTEK, as described below.
Adults with psoriasis or psoriatic arthritis, and children 6 years and older with psoriasis or psoriatic arthritis will receive YESINTEK as an injection under the skin (subcutaneous injection) as described below.

Injecting YESINTEK under your skin:

YESINTEK is intended for use under the guidance and supervision of your doctor. In children 6 years and older, it is recommended that YESINTEK be administered by a healthcare provider. If your doctor decides that you or a caregiver may give your injections of YESINTEK at home, you should receive training on the right way to prepare and inject YESINTEK. Your doctor will determine the right dose of YESINTEK for you, the amount for each injection, and how often you should receive it. Do not try to inject YESINTEK yourself until you or your caregiver have been shown how to inject YESINTEK by your doctor or nurse.
Inject YESINTEK under the skin (subcutaneous injection) in your upper arms, buttocks, upper legs (thighs) or stomach area (abdomen).
Do not give an injection in an area of the skin that is tender, bruised, red or hard.
Use a different injection site each time you use YESINTEK.
If you inject more YESINTEK than prescribed, call your doctor right away.
Be sure to keep all of your scheduled follow-up appointments.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch or call 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

READ MORE +

SHOW LESS -

YESINTEK is a prescription medicine that affects your immune system. YESINTEK can increase your chance of having serious side effects including:

Serious Infections

YESINTEK may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have serious infections, which may require hospitalization, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses. Some people have to be hospitalized for treatment of their infection.

Your doctor should check you for TB before starting YESINTEK.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with YESINTEK and during treatment with YESINTEK.
Your doctor should watch you closely for signs and symptoms of TB while you are being treated with YESINTEK.

You should not start taking YESINTEK if you have any kind of infection unless your doctor says it is okay.

Before starting YESINTEK, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

fever, sweats, or chills
muscle aches
cough
shortness of breath
blood in phlegm
weight loss

warm, red, or painful skin or sores on your body
diarrhea or stomach pain
burning when you urinate or urinate more often than normal
feel very tired

are being treated for an infection or have any open cuts.
get a lot of infections or have infections that keep coming back.
have TB or have been in close contact with someone with TB.

After starting YESINTEK, call your doctor right away if you have any symptoms of an infection (see above). These may be signs of infections such as chest infections, or skin infections or shingles that could have serious complications. YESINTEK can make you more likely to get infections or make an infection that you have worse.
People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections. These infections can spread throughout the body and cause death. People who take YESINTEK may also be more likely to get these infections.

Cancers: YESINTEK may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who are receiving ustekinumab products and have risk factors for skin cancer developed certain types of skin cancers. During your treatment with YESINTEK, tell your doctor if you have any new skin growths.

Posterior Reversible Encephalopathy Syndrome (PRES): PRES is a rare condition that affects the brain and can cause death. The cause of PRES is not known. If PRES is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including headache, seizures, confusion, and vision problems.

Serious Allergic Reactions: Serious allergic reactions can occur with YESINTEK. Stop using YESINTEK and get medical help right away if you have any symptoms of a serious allergic reaction such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Common side effects of YESINTEK include: nasal congestion, sore throat, and runny nose, redness at the injection site, upper respiratory infections, vaginal, yeast infections, fever, urinary tract infections, headache, sinus infection, tiredness, bronchitis, itching, diarrhea, nausea and vomiting, stomach pain. These are not all of the possible side effects with YESINTEK. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Before you receive YESINTEK, tell your doctor about all of your medical conditions, including if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or PRES.
ever had an allergic reaction to ustekinumab or any of its ingredients. Ask your doctor if you are not sure.
have recently received or are scheduled to receive an immunization (vaccine). People who take YESINTEK should not receive live vaccines. Tell your doctor if anyone in your house needs a live vaccine. The viruses used in some types of live vaccines can spread to people with a weakened immune system and can cause serious problems. You should not receive the BCG vaccine during the one year before receiving YESINTEK or one year after you stop receiving YESINTEK.
have any new or changing lesions within psoriasis areas or on normal skin.
are receiving or have received allergy shots, especially for serious allergic reactions. Allergy shots may not work as well for you during treatment with YESINTEK. YESINTEK may also increase your risk of having an allergic reaction to an allergy shot.
receive or have received phototherapy for your psoriasis.
are pregnant or plan to become pregnant. It is not known if YESINTEK can harm your unborn baby. You and your doctor should decide if you will receive YESINTEK.
received YESINTEK while you were pregnant. It is important that you tell your baby’s healthcare provider before any vaccinations are given to your baby.
are breastfeeding or plan to breastfeed. YESINTEK can pass into your breast milk.
talk to your doctor about the best way to feed your baby if you receive YESINTEK.

When prescribed YESINTEK:

Use YESINTEK exactly as your doctor tells you to.
Adults with Crohn’s disease and ulcerative colitis will receive the first dose of YESINTEK through a vein in the arm (intravenous infusion) in a healthcare facility by a healthcare provider. It takes at least 1 hour to receive the full dose of medicine. You will then receive YESINTEK as an injection under the skin (subcutaneous injection) 8 weeks after the first dose of YESINTEK, as described below.
Adults with psoriasis or psoriatic arthritis, and children 6 years and older with psoriasis or psoriatic arthritis will receive YESINTEK as an injection under the skin (subcutaneous injection) as described below.

Injecting YESINTEK under your skin:

YESINTEK is intended for use under the guidance and supervision of your doctor. In children 6 years and older, it is recommended that YESINTEK be administered by a healthcare provider. If your doctor decides that you or a caregiver may give your injections of YESINTEK at home, you should receive training on the right way to prepare and inject YESINTEK. Your doctor will determine the right dose of YESINTEK for you, the amount for each injection, and how often you should receive it. Do not try to inject YESINTEK yourself until you or your caregiver have been shown how to inject YESINTEK by your doctor or nurse.
Inject YESINTEK under the skin (subcutaneous injection) in your upper arms, buttocks, upper legs (thighs) or stomach area (abdomen).
Do not give an injection in an area of the skin that is tender, bruised, red or hard.
Use a different injection site each time you use YESINTEK.
If you inject more YESINTEK than prescribed, call your doctor right away.
Be sure to keep all of your scheduled follow-up appointments.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch
or call 1-800-FDA-1088.

WHAT IS YESINTEK (ustekinumab-kfce)?

IMPORTANT SAFETY INFORMATION

YESINTEK is a prescription medicine that affects your immune system. YESINTEK can increase your chance of having serious side effects including:

Serious Infections

Your doctor should check you for TB before starting YESINTEK.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with YESINTEK and during treatment with YESINTEK.
Your doctor should watch you closely for signs and symptoms of TB while you are being treated with YESINTEK.

You should not start taking YESINTEK if you have any kind of infection unless your doctor says it is okay.

Before starting YESINTEK, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

fever, sweats, or chills
muscle aches
cough
shortness of breath
blood in phlegm
weight loss

warm, red, or painful skin or sores on your body
diarrhea or stomach pain
burning when you urinate or urinate more often than normal
feel very tired

are being treated for an infection or have any open cuts.
get a lot of infections or have infections that keep coming back.
have TB or have been in close contact with someone with TB.

After starting YESINTEK, call your doctor right away if you have any symptoms of an infection (see above). These may be signs of infections such as chest infections, or skin infections or shingles that could have serious complications. YESINTEK can make you more likely to get infections or make an infection that you have worse.
People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections. These infections can spread throughout the body and cause death. People who take YESINTEK may also be more likely to get these infections.

Cancers: YESINTEK may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who are receiving ustekinumab products and have risk factors for skin cancer developed certain types of skin cancers. During your treatment with YESINTEK, tell your doctor if you have any new skin growths.

Posterior Reversible Encephalopathy Syndrome (PRES): PRES is a rare condition that affects the brain and can cause death. The cause of PRES is not known. If PRES is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including headache, seizures, confusion, and vision problems.

Serious Allergic Reactions: Serious allergic reactions can occur with YESINTEK. Stop using YESINTEK and get medical help right away if you have any symptoms of a serious allergic reaction such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Common side effects of YESINTEK include: nasal congestion, sore throat, and runny nose, redness at the injection site, upper respiratory infections, vaginal, yeast infections, fever, urinary tract infections, headache, sinus infection, tiredness, bronchitis, itching, diarrhea, nausea and vomiting, stomach pain. These are not all of the possible side effects with YESINTEK. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Before you receive YESINTEK, tell your doctor about all of your medical conditions, including if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or PRES.
ever had an allergic reaction to ustekinumab or any of its ingredients. Ask your doctor if you are not sure.
have recently received or are scheduled to receive an immunization (vaccine). People who take YESINTEK should not receive live vaccines. Tell your doctor if anyone in your house needs a live vaccine. The viruses used in some types of live vaccines can spread to people with a weakened immune system and can cause serious problems. You should not receive the BCG vaccine during the one year before receiving YESINTEK or one year after you stop receiving YESINTEK.
have any new or changing lesions within psoriasis areas or on normal skin.
are receiving or have received allergy shots, especially for serious allergic reactions. Allergy shots may not work as well for you during treatment with YESINTEK. YESINTEK may also increase your risk of having an allergic reaction to an allergy shot.
receive or have received phototherapy for your psoriasis.
are pregnant or plan to become pregnant. It is not known if YESINTEK can harm your unborn baby. You and your doctor should decide if you will receive YESINTEK.
received YESINTEK while you were pregnant. It is important that you tell your baby’s healthcare provider before any vaccinations are given to your baby.
are breastfeeding or plan to breastfeed. YESINTEK can pass into your breast milk.
talk to your doctor about the best way to feed your baby if you receive YESINTEK.

When prescribed YESINTEK:

Use YESINTEK exactly as your doctor tells you to.
Adults with Crohn’s disease and ulcerative colitis will receive the first dose of YESINTEK through a vein in the arm (intravenous infusion) in a healthcare facility by a healthcare provider. It takes at least 1 hour to receive the full dose of medicine. You will then receive YESINTEK as an injection under the skin (subcutaneous injection) 8 weeks after the first dose of YESINTEK, as described below.
Adults with psoriasis or psoriatic arthritis, and children 6 years and older with psoriasis or psoriatic arthritis will receive YESINTEK as an injection under the skin (subcutaneous injection) as described below.

Injecting YESINTEK under your skin:

YESINTEK is intended for use under the guidance and supervision of your doctor. In children 6 years and older, it is recommended that YESINTEK be administered by a healthcare provider. If your doctor decides that you or a caregiver may give your injections of YESINTEK at home, you should receive training on the right way to prepare and inject YESINTEK. Your doctor will determine the right dose of YESINTEK for you, the amount for each injection, and how often you should receive it. Do not try to inject YESINTEK yourself until you or your caregiver have been shown how to inject YESINTEK by your doctor or nurse.
Inject YESINTEK under the skin (subcutaneous injection) in your upper arms, buttocks, upper legs (thighs) or stomach area (abdomen).
Do not give an injection in an area of the skin that is tender, bruised, red or hard.
Use a different injection site each time you use YESINTEK.
If you inject more YESINTEK than prescribed, call your doctor right away.
Be sure to keep all of your scheduled follow-up appointments.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit https://www.fda.gov/medwatch
or call 1-800-FDA-1088.

Welcome toYes

REFERENCES

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION

WHAT IS YESINTEK (ustekinumab-kfce)?

IMPORTANT SAFETY INFORMATION

WHAT IS YESINTEK (ustekinumab-kfce)?

You are now leaving www.YESINTEK.com, a Biocon Biologics website. The website you are about to access is not owned or controlled by Biocon Biologics Inc.

You are now leaving www.YESINTEK.com, a Biocon Biologics website. The website you are about to access is not owned or controlled by Biocon Biologics Inc.

INDICATIONS

INDICATIONS